Ultrastructure of human endometrium in cases of dysfunctional uterine bleeding having normal light microscopic findings

The ultrastructure of endometrial biopsies from 20 women suffering from dysfunctional uterine bleeding and diagnosed as being histologically normal by light microscopy were studied by transmission electron microscopy. The gl and cells showed enlarged mitochondria and defect in the development of nucleolar channel system. The blood vessels exhibited early degenerative changes of endothelial cells and focally disrupted areas of basement membrane. Open junction between endothelial cells were frequently observed; thus, electron microscopic examination revealed that vessel damage plays a major role in dysfunctional uterine bleeding. Delay in maturation of some gl and cells with consequent delay in healing resulting in prolonged bleeding was suggested as another factor. It was concluded that in endometria of women suffering from dysfunctional uterine bleeding, electron microscopy might reveal structural abnormalities not revealed by ordinary light microscopy. The clinical impact of those observed electron microscopic changes needs further elucidation

Effect of prolonged period of starvation on the structure of the testis of albino rat

The adult male albino rats with an average weight of 300 gm were subjected to complete food removal for 7, 11 and 15 days. The testes were then examined histologically and histochemically. The first effect of starvation on the testes was progressive shrinkage of the seminiferous tubule. However, each stage in the maturation process was still evident, especially after 7 days of starvation. After 11, 15 days of starvation there was increased destruction of the luminal cells and the tubular sizes were diminished. These changes were accompanied with progressive thickening of both basement membrane of the seminiferous tubules and the testicular capsule. Additionally there was a marked fibrosis of the interstitial connective tissue. The interstitial Leydig cells were gradually shrank and became masked by the fibrosis

Effect of induced hyperthermia on microscopic structure of some parenchymatous organs in albino rats

Forty adult albino rats of both sexes were used in this study [10 females and 30 males]. Thirty of them [5 females 7 25 males] were exposed to hyperthermia six hours daily for 10 days while the remaining animals were kept as control. Six rats per time were sacrificed after 2, 4, 6, 8 and 10 days from heat exposure. Microscopical examination of heart, lungs, liver kidneys, adrenals, pancreas, uteri, ovaries and testes were carried out in all animals. Pathological lesions were found in the lung, kidney, adrenal, liver, and testis in the form of varying degrees of congestion, haemorrhage, oedema, degeneration and arrested spermatogenesis. These pathological lesions became more marked with increasing the period of heat exposure